A Game with a Purpose: Designing Structural Modifications in Polymyxin B to Face Multi-Drug Resistant Bacteria

Author:

Machado Inês1ORCID,Inácio João23,Jorge Paula34ORCID,Teixeira Filipe2ORCID

Affiliation:

1. Institute for Polymers and Composites, University of Minho, 4800-058 Guimarães, Portugal

2. Centre of Chemistry, University of Minho, 4710-057 Braga, Portugal

3. Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal

4. LABBELS—Associate Laboratory, Braga/Guimarães, Portugal

Publisher

MDPI

Reference6 articles.

1. Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence;Garg;Crit. Care Res. Pract.,2017

2. Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane;Manioglu;Nat. Commun.,2022

3. Structure-Activity Relationships of Polymyxin Antibiotics;Velkov;J. Med. Chem.,2010

4. PubChem 2023 update;Kim;Nucleic Acids Res.,2022

5. The Molecular Connectivity Chi Indexes and Kappa Shape Indexes in Structure-Property Modeling;Lipkowitz;Reviews in Computational Chemistry,1991

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