Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk-Reference-Cited by-同舟云学术

Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk

Published:2024-05-21 Issue:11 Volume:16 Page:1552
ISSN:2072-6643
Container-title:Nutrients
language:en
Short-container-title:Nutrients

Author:

de Luis Roman Daniel¹²^ORCID,García Almeida José Manuel³^ORCID,Bellido Guerrero Diego⁴^ORCID,Guzmán Rolo Germán⁵^ORCID,Martín Andrea⁵,Primo Martín David¹²^ORCID,García-Delgado Yaiza⁶^ORCID,Guirado-Peláez Patricia³⁷,Palmas Fiorella⁸,Tejera Pérez Cristina⁴⁹^ORCID,García Olivares María⁷¹⁰¹¹^ORCID,Maíz Jiménez María¹²^ORCID,Bretón Lesmes Irene¹³^ORCID,Alzás Teomiro Carlos Manuel¹⁴^ORCID,Guardia Baena Juan Manuel¹⁵^ORCID,Calles Romero Laura A.¹⁶,Prior-Sánchez Inmaculada¹⁷,García-Luna Pedro Pablo¹⁸^ORCID,González Pacheco María¹⁹²⁰,Martínez-Olmos Miguel Ángel²¹²²²³^ORCID,Alabadí Blanca²⁴²⁵^ORCID,Alcántara-Aragón Valeria²⁶^ORCID,Palma Milla Samara²⁷,Martín Folgueras Tomás²⁸,Micó García Andrea²⁹,Molina-Baena Begoña³⁰,Rendón Barragán Henry³¹,Rodríguez de Vera Gómez Pablo³²^ORCID,Riestra Fernández María³³³⁴^ORCID,Jiménez Portilla Ana³⁵,López-Gómez Juan J.¹²^ORCID,Pérez Martín Nuria⁶^ORCID,Montero Madrid Natalia³⁷³⁶,Zabalegui Eguinoa Alba⁸,Porca Fernández Cristina⁴⁹³⁷^ORCID,Tapia Guerrero María José⁷¹⁰^ORCID,Ruiz Aguado Marta¹²³⁸,Velasco Gimeno Cristina¹³^ORCID,Herrera Martínez Aura D¹⁴³⁹^ORCID,Novo Rodríguez María¹⁵,Iglesias Hernández Natalia C.¹⁶,de Damas Medina María¹⁷,González Navarro Irene¹⁸,Vílchez López Francisco Javier¹⁹²⁰,Fernández-Pombo Antía²¹^ORCID,Olveira Gabriel⁷¹⁰³⁶⁴⁰^ORCID

Affiliation:

1. Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain

2. Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain

3. Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain

4. Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de Ferrol (CHUF), 15405 Ferrol, A Coruña, Spain

5. Medical Department, Abbott Laboratories, 28050 Madrid, Spain

6. Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular-Materno Infantil, 35016 Gran Canaria, Spain

7. Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Málaga, Spain

8. Endocrinology and Nutrition Department, Hospital Universitari Vall D’Hebron, 08036 Barcelona, Spain

9. Epigenomics in Endocrinology and Nutrition Group, Santiago Health Research Institute (IDIS), 34113 Santiago de Compostela, Spain

10. Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain

11. Department of Medicine and Surgery, Malaga University, 29010 Malaga, Spain

12. Department of Endocrinology and Nutrition, University Hospital 12 de Octubre, 28041 Madrid, Spain

13. Endocrinology and Nutrition Unit, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain

14. Reina Sofía University Hospital, 14004 Córdoba, Spain

15. Service of Endocrinology and Nutrition, University Hospital Virgen de las Nieves, 41013 Granada, Spain

16. Endocrinology and Nutrition Service, Basurto University Hospital, 48903 Bilbao, Spain

17. Endocrinology Service, Complejo Hospitalario de Jaén, 23007 Jaén, Spain

18. Endocrinology and Nutrition Clinical Management Unit, Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC/University of Seville, 41013 Seville, Spain

19. Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain

20. Biomedical Research and Innovation Institute of Cádiz (INiBICA), 11009 Cádiz, Spain

21. Division of Endocrinology and Nutrition, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain

22. Molecular Endocrinology Research Group, Health Research Institute of Santiago de Compostela-IDIS, 15706 Santiago de Compostela, Spain

23. CIBERObn, National Health Institute Carlos III, 28031 Madrid, Spain

24. Service of Endocrinology and Nutrition, Hospital Clínico Universitario of Valencia, 46010 Valencia, Spain

25. INCLIVA Biomedical Research Institute, 46010 Valencia, Spain

26. Endocrinology and Nutrition Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain

27. Clinical Nutrition and Dietetics Unit, Endocrinology and Nutrition Service, University Hospital of La Paz, 28046 Madrid, Spain

28. Endocrinology and Nutrition Service, Hospital Universitario de Canarias, 38320 Tenerife, Spain

29. Endocrinology and Nutrition Service, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain

30. Deparment of Endocrinology and Nutrition, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain

31. Endocrinology and Nutrition, FEA Endocrinology and Nutrition, Navarra University Hospital, 31008 Pamplona, Spain

32. Endocrinology and Nutrition Service, Virgen Macarena University Hospital, 41009 Seville, Spain

33. Endocrinology Service, Cabueñes University Hospital, 33394 Gijón, Spain

34. Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain

35. Endocrinology and Nutrition Service, Consorci Hospital General Universitari de València, 46014 Valencia, Spain

36. Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, 29010 Málaga, Spain

37. Professor Novoa Santos Foundation, 15405 A Coruña, Spain

38. i+12 Research Institute, 28041 Madrid, Spain

39. Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain

40. CIBER of Diabetes and Associated Metabolic Diseases, Carlos III Health Institute, 28029 Madrid, Spain

Abstract

Background: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound of the rectus femoris for detecting sarcopenia in hospitalized patients at risk of malnutrition and to define cut-off values of ultrasound measures. Methods: Patients at risk of malnutrition according to the Malnutrition Universal Screening Tool (MUST) underwent handgrip dynamometry, bioelectrical impedance analysis (BIA), a Timed Up and Go (TUG) test, and rectus femoris ultrasound studies. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were used to define categories of sarcopenia (at risk, probable, confirmed, severe). Receiver operating characteristic (ROC) and area under the curve (AUC) analyses were used to determine the optimal diagnostic sensitivity, specificity, and predictive values of cut-off points of the ultrasound measures for the detection of risk of sarcopenia and probable, confirmed, and severe sarcopenia. Results: A total of 1000 subjects were included and 991 of them (58.9% men, mean age 58.5 years) were evaluated. Risk of sarcopenia was detected in 9.6% patients, probable sarcopenia in 14%, confirmed sarcopenia in 9.7%, and severe sarcopenia in 3.9%, with significant differences in the distribution of groups between men and women (p < 0.0001). The cross-sectional area (CSA) of the rectus femoris showed a significantly positive correlation with body cell mass of BIA and handgrip strength, and a significant negative correlation with TUG. Cut-off values were similar within each category of sarcopenia, ranging between 2.40 cm2 and 3.66 cm2 for CSA, 32.57 mm and 40.21 mm for the X-axis, and 7.85 mm and 10.4 mm for the Y-axis. In general, these cut-off values showed high sensitivities, particularly for the categories of confirmed and severe sarcopenia, with male patients also showing better sensitivities than women. Conclusions: Sarcopenia in hospitalized patients at risk of malnutrition was high. Cut-off values for the better sensitivities and specificities of ultrasound measures of the rectus femoris are established. The use of ultrasound of the rectus femoris could be used for the prediction of sarcopenia and be useful to integrate nutritional study into real clinical practice.

Funder

Abbott Laboratories

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6643/16/11/1552/pdf

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