Author:
Goodwin Christopher,Ciesla Jessica,Munger Joshua
Abstract
As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain.
Funder
National Institute of Allergy and Infectious Diseases
American Cancer Society
Subject
Virology,Infectious Diseases
Cited by
30 articles.
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