Affiliation:
1. Otolaryngology-Head and Neck Surgery Hospital of Hainan Province, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, China
Abstract
We aimed to characterize the clinical profiles and short-term outcomes of adult patients with full-frequency idiopathic sudden sensorineural hearing loss (ISSNHL) treated uniformly with combination therapy, and to determine the prognostic predictors for the combination therapy. A total of 131 eligible cases hospitalized in our department from January 2018 to June 2021 were retrospectively reviewed. All enrolled cases received a standardized combination therapy employing intravenous methylprednisolone, batroxobin, and Ginkgo biloba extract during the 12 days of hospitalization. The clinical and audiometric profiles were compared between recovered patients and their unrecovered counterparts. The overall recovery rate was 57.3% in the study. Accompanying vertigo (odds ratio = 0.360, p = 0.006) and body mass index (BMI, odds ratio = 1.158, p = 0.016) were two independent predictors of hearing outcomes of the therapy. The male gender and cigarette-smoking history were marginally associated with good hearing prognosis (p = 0.051 and 0.070, respectively). Patients with BMI ≥ 22.4 kg/m2 had a better chance of hearing recovery (p = 0.02). Conclusions: Accompanying vertigo and low BMI (<22.4 kg/m2) were independently associated with poor prognosis for full-frequency ISSNHL in combination therapy. Male gender and cigarette-smoking history might be considered positive effects on hearing prognosis.
Funder
National Natural Science Foundation of China
Reference27 articles.
1. Clinical practice guideline: Sudden hearing loss (Update);Chandrasekhar;Otolaryngol. Head Neck Surg.,2019
2. Analysis of clinical and laboratory findings of idiopathic sudden sensorineural hearing loss;Xie;Sci. Rep.,2020
3. Sudden sensorineural hearing loss;Schreiber;Lancet,2010
4. Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery (2015). Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association [Guideline of diagnosis and treatment of sudden deafness (2015)]. Chin. J. Otorhinolaryngol. Head Neck Surg., 50, 443–447.
5. International consensus (ICON) on treatment of sudden sensorineural hearing loss;Marx;Eur. Ann. Otorhinolaryngol. Head Neck Dis.,2018
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献