COVID-19-Related Neuropathic Pain: A Systematic Review and Meta-Analysis

Author:

Williams Laura1,Zis Panagiotis123ORCID

Affiliation:

1. Medical School, University of Sheffield, Sheffield S10 2RX, UK

2. Medical School, University of Cyprus, Nicosia 2029, Cyprus

3. Second Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece

Abstract

Introduction: SARS-CoV-2, responsible for the coronavirus disease (COVID-19) pandemic, may impact other systems apart from the respiratory system, including the nervous system. In this systematic review, we aimed to establish the prevalence and determinants of neuropathic pain amongst COVID-19-infected individuals. Methodology: A literature search in the PubMed database was performed and 11 papers were eligible for inclusion in this systematic review and meta-analysis. Results: The pooled prevalence of COVID-19-related neuropathic pain was 6.7% (95% CI: 4.7–9.5%) for hospitalised patients during the acute phase and 34.3% (95% CI: 14.3–62%) for long COVID patients. The identified risk factors for COVID-19-related neuropathic pain development included depression, COVID-19 severity and azithromycin use. Conclusions: Neuropathic pain is a very common symptom in long COVID, indicating the urgency for further research in this direction.

Publisher

MDPI AG

Subject

General Medicine

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