Ultra-Wide-Field Fluorescein Angiography Assessment of Non-Perfusion in Patients with Diabetic Retinopathy Treated with Anti-Vascular Endothelial Growth Factor Therapy

Author:

Morel Jean-Baptiste1,Fajnkuchen Franck1ORCID,Amari Fatima1,Sritharan Nanthara2,Bloch-Queyrat Coralie2,Giocanti-Aurégan Audrey1ORCID

Affiliation:

1. Ophthalmology Department, Paris Seine Saint Denis Hospital, Sorbonne Paris Nord University, 125 Rue de Stalingrad, 93000 Bobigny, France

2. Department of Clinical Research, Paris Seine Saint Denis Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 93000 Bobigny, France

Abstract

Purpose: To follow the evolution of peripheral ischemia by fluorescein angiography (FA) on ultra-wide-field (UWF) images in diabetic patients treated with anti-vascular endothelial growth factor (anti-VEGF) for macular edema. Methods: Prospective, non-interventional cohort study analyzing UWF-FA images of 48 patients with diabetic retinopathy (48 eyes) treated for diabetic macular edema. UWF-FA was performed at baseline and after one year of anti-VEGF therapy (M12). The primary endpoint was the change in the non-perfusion index. Results: Of the 48 patients included in this study, 25 completed the one-year follow-up, and 20 had FA images of sufficient quality to be interpreted. The non-perfusion index did not significantly change from baseline after one year of anti-VEGF treatment (0.7% of the non-perfused area at baseline versus 0.5% at M12; p = 0.29). In contrast, the diabetic retinopathy severity score improved significantly between baseline and M12. Conclusions: Anti-VEGF treatment with aflibercept for diabetic macular edema had no impact on the retinal perfusion assessed by FA, but it allowed for artificially improving diabetic retinopathy severity scores.

Funder

BAYER HEALTHCARE SAS

Publisher

MDPI AG

Subject

General Medicine

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