Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis

Author:

Frajerman Ariel1ORCID,Chaumette Boris123ORCID,Farabos Dominique4,Despres Gaétan4,Simonard Christelle4,Lamazière Antonin4,Krebs Marie-Odile12,Kebir Oussama12

Affiliation:

1. Institute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM U1266, F-75014 Paris, France

2. GHU Paris Psychiatrie et Neurosciences, F-75674 Paris, France

3. Department of Psychiatry, McGill University, Montréal, QC H3A 0G4, Canada

4. INSERM UMR S 938, Département METOMICS, Centre de Recherche Saint-Antoine, Sorbonne Université, AP–HP, F-75012 Paris, France

Abstract

Alterations in membrane lipids are reported in schizophrenia. However, no conclusion can be drawn regarding the extended and predictive value of these alterations in persons at ultra-high risk of psychosis (UHR). Recent studies suggested that sterols’ impact on psychiatric disorders was underestimated. Here, we simultaneously explored sterols, fatty acids (FA), and phospholipids (PL) in UHR persons for the first time. We analysed erythrocyte membrane lipids in 61 UHR persons, including 29 who later converted to psychosis (UHR-C) and 32 who did not (UHC-NC). We used gas chromatography for FA and liquid chromatography tandem with mass spectrometry for sterols and phospholipids. Among UHR individuals, elevated baseline membrane linoleic acid level was associated with conversion to psychosis (26.1% vs. 60.5%, p = 0.02). Combining sterols, FA, and PL membrane composition improved the prediction of psychosis onset (AUC = 0.73). This is the first report showing that membrane sterol participates, with other membrane lipids, in modulating the risk of psychosis. It suggests that membrane lipids could be used as biomarkers for personalised medicine in UHR patients.

Funder

French government’s program for clinical research PHRC ICAAR

“Investissements d’Avenir” PsyCARE program

Agence Nationale de la Recherche

Agence Régionale de Santé

Fondation Bettencourt Schueller

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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