Effect of Nutraceutical Factors on Hepatic Intermediary Metabolism in Wistar Rats with Induced Tendinopathy
-
Published:2024-01-03
Issue:1
Volume:25
Page:629
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Ramos-Barbero Marta1, Rufino-Palomares Eva E.1ORCID, Serrano-Carmona Sergio2, Hernández-Yera Manuel1, García-Salguero Leticia1, Lupiáñez José Antonio1ORCID, Pérez-Jiménez Amalia3ORCID
Affiliation:
1. Department of Biochemistry and Molecular Biology I, Faculty of Science, University of Granada, 18071 Granada, Spain 2. Sergio Serrano Fisiomedicina Avanzada, Physiotherapy Clinic, 41011 Sevilla, Spain 3. Department of Zoology, Faculty of Science, University of Granada, 18071 Granada, Spain
Abstract
Tendinopathy (TP) is a complex clinical syndrome characterized by local inflammation, pain in the affected area, and loss of performance, preceded by tendon injury. The disease develops in three phases: Inflammatory phase, proliferative phase, and remodeling phase. There are currently no proven treatments for early reversal of this type of injury. However, the metabolic pathways of the transition metabolism, which are necessary for the proper functioning of the organism, are known. These metabolic pathways can be modified by a number of external factors, such as nutritional supplements. In this study, the modulatory effect of four dietary supplements, maslinic acid (MA), hydroxytyrosol (HT), glycine, and aspartate (AA), on hepatic intermediary metabolism was observed in Wistar rats with induced tendinopathy at different stages of the disease. Induced tendinopathy in rats produces alterations in the liver intermediary metabolism. Nutraceutical treatments modify the intermediary metabolism in the different phases of tendinopathy, so AA treatment produced a decrease in carbohydrate metabolism. In lipid metabolism, MA and AA caused a decrease in lipogenesis at the tendinopathy and increased fatty acid oxidation. In protein metabolism, MA treatment increased GDH and AST activity; HT decreased ALT activity; and the AA treatment does not cause any alteration. Use of nutritional supplements of diet could help to regulate the intermediary metabolism in the TP.
Funder
Regional Government of Andalusia
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference51 articles.
1. Inflammation in tendinopathy;Maffulli;Surgeon,2017 2. Current opinions on tendinopathy;Kaux;J. Sports Sci. Med.,2011 3. Steinmann, S., Pfeifer, C.G., Brochhausen, C., and Docheva, D. (2020). Spectrum of tendon pathologies: Triggers, trails and end-state. Int. J. Mol. Sci., 21. 4. The association between the COL12A1 gene and anterior cruciate ligament ruptures;Posthumus;Br. J. Sports Med.,2010 5. Achilles Tendinopathy: Evaluation, Rehabilitation, and Prevention;Borgstrom;Curr. Sports Med. Rep.,2021
|
|