Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery-Reference-Cited by-同舟云学术

Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery

Published:2023-12-23 Issue:1 Volume:25 Page:246
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Constantinescu Sorin¹,Niculescu Adelina-Gabriela²³^ORCID,Hudiță Ariana²⁴^ORCID,Grumezescu Valentina⁵,Rădulescu Dragoș¹,Bîrcă Alexandra Cătălina³,Irimiciuc Stefan Andrei⁵^ORCID,Gherasim Oana⁵,Holban Alina Maria²⁶,Gălățeanu Bianca⁴^ORCID,Oprea Ovidiu Cristian⁷⁸^ORCID,Ficai Anton³⁸^ORCID,Vasile Bogdan Ștefan³^ORCID,Grumezescu Alexandru Mihai²³⁸^ORCID,Bolocan Alexandra¹,Rădulescu Radu¹

Affiliation:

1. Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari St. 8, 050474 Bucharest, Romania

2. Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania

3. Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Gh. Polizu St. 1-7, 060042 Bucharest, Romania

4. Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania

5. Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor St., 077125 Magurele, Romania

6. Microbiology and Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Portocalelor Lane, District 5, 77206 Bucharest, Romania

7. Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 1-7 Polizu St., 011061 Bucharest, Romania

8. Academy of Romanian Scientists, Spl. Independenței 54, 50085 Bucharest, Romania

Abstract

Exploring silver-based and carbon-based nanomaterials’ excellent intrinsic antipathogenic effects represents an attractive alternative for fabricating anti-infective formulations. Using chemical synthesis protocols, stearate-conjugated silver (Ag@C18) nanoparticles and graphene oxide nanosheets (nGOs) were herein obtained and investigated in terms of composition and microstructure. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterizations revealed the formation of nanomaterials with desirable physical properties, while X-ray diffraction (XRD) analyses confirmed the high purity of synthesized nanomaterials. Further, laser-processed Ag@C18-nGO coatings were developed, optimized, and evaluated in terms of biological and microbiological outcomes. The highly biocompatible Ag@C18-nGO nanostructured coatings proved suitable candidates for the local modulation of biofilm-associated periprosthetic infections.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/25/1/246/pdf

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