Future Role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective

Author:

Husereau Don1ORCID,Bombard Yvonne23,Stockley Tracy45ORCID,Carter Michael6ORCID,Davey Scott789,Lemaire Diana10,Nohr Erik1112ORCID,Park Paul13,Spatz Alan141516ORCID,Williams Christine710,Pollett Aaron1718ORCID,Lo Bryan19,Yip Stephen20ORCID,El Hallani Soufiane21ORCID,Feilotter Harriet710ORCID

Affiliation:

1. School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada

2. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5T 3M6, Canada

3. Genomics Health Services Research Program, Li Ka Shing Knowledge Institute, Michael’s Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada

4. Division of Clinical Laboratory Genetics, Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada

5. Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada

6. Department of Pathology and Laboratory Medicine, Nova Scotia Health (Central Zone), Halifax, NS B3H 1V8, Canada

7. Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada

8. Division of Cancer Biology and Genetics, Queen’s University Cancer Research Institute, Queen’s University, Kingston, ON K7L 3N6, Canada

9. Departments of Oncology and Biomedical and Molecular Sciences, Queen’s University Cancer Research Institute, Queen’s University, Kingston, ON K7L 2V7, Canada

10. Ontario Institute for Cancer Research, 661 University Ave, Toronto, ON M5G 0A3, Canada

11. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada

12. Alberta Precision Laboratories, Foothills Medical Center, 1403 29 St NW, Calgary, AB T2N 2T9, Canada

13. Department of Pathology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, Canada

14. Division of Pathology, McGill University Health Center, 1001 Decarie Blvd., Montreal, QC H4A 3J, Canada

15. OPTILAB-MUHC & Department of Laboratory Medicine, 1001 Decarie Blvd., Montreal, QC H4A 3J, Canada

16. Research Molecular Pathology Center, Lady Davis Institute, 3755 Côte Ste-Catherine Road, Montreal, QC H3T 1E2, Canada

17. Pathology & Laboratory Medicine, Sinai Health System, Toronto, ON M5G 1X5, Canada

18. Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada

19. The Ottawa General Hospital, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada

20. Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada

21. Alberta Precision Laboratory, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R7, Canada

Abstract

Genome-based testing in oncology is a rapidly expanding area of health care that is the basis of the emerging area of precision medicine. The efficient and considered adoption of novel genomic medicine testing is hampered in Canada by the fragmented nature of health care oversight as well as by lack of clear and transparent processes to support rapid evaluation, assessment, and implementation of genomic tests. This article provides an overview of some key barriers and proposes approaches to addressing these challenges as a potential pathway to developing a national approach to genomic medicine in oncology.

Funder

Canadian Cancer Society

Publisher

MDPI AG

Reference37 articles.

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4. Health Quality Ontario (2019). Noninvasive Prenatal Testing for Trisomies 21, 18, and 13, Sex Chromosome Aneuploidies, and Microdeletions: A Health Technology Assessment. Ont. Health Technol. Assess. Ser., 19, 1.

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