CAR-T Cells in Canada; Perspective on How to Ensure We Get Our Value’s Worth

Author:

Villeneuve Pierre J. A.12ORCID,Bredeson Christopher12ORCID

Affiliation:

1. Division of Hematology, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada

2. School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada

Abstract

New therapies in a publicly funded healthcare system are first appraised by health technology assessment agencies that provide funding recommendations to the payers. Treatment with Chimeric Antigen Receptor-T cell (CAR-T) therapy is revolutionizing the management of patients with relapsed/refractory aggressive B-cell lymphoma by providing an effective alternative to the standard of care. Yet, the implementation of CAR-T treatment has a substantial impact on the healthcare system due to its high cost, complex manufacturing process, and requirement for highly specialized services and expertise. CAR-T Cells, as a “living drug”, are fundamentally different from usual medications, and their approvals and funding recommendations pose unique challenges to the health technology agency. In this paper, we explore the specific challenges that face the health technology agencies in reviewing reimbursement recommendations for CAR-T therapy. We take a Canadian perspective and use CAR-T treatment of relapse/refractory aggressive B-cell lymphoma as an example.

Publisher

MDPI AG

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