Consensus Recommendations to Optimize the Detection and Reporting of NTRK Gene Fusions by RNA-Based Next-Generation Sequencing

Author:

Stockley Tracy L.123ORCID,Lo Bryan4,Box Adrian5,Gomez Corredor Andrea6,DeCoteau John7,Desmeules Patrice8,Feilotter Harriet910ORCID,Grafodatskaya Daria1112,Hawkins Cynthia213,Huang Weei Yuarn21415ORCID,Izevbaye Iyare16,Lepine Guylaine17,Papadakis Andreas I.18ORCID,Park Paul C.19,Sheffield Brandon S.20,Tran-Thanh Danh21,Yip Stephen2223ORCID,Sound Tsao Ming12ORCID

Affiliation:

1. Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada

2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5R 0A3, Canada

3. Advanced Molecular Diagnostics Laboratory, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada

4. Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada

5. Alberta Precision Laboratories, Calgary, AB T2N 7A4, Canada

6. McGill University Health Center, Montreal, QC H4A 3J1, Canada

7. Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada

8. IUCPQ-UL, Quebec Heart and Lung Institute, Quebec City, QC G1V 4G5, Canada

9. Kingston Health Sciences Centre, Kingston, ON K7L 2V7, Canada

10. Department of Pathology and Molecular Medicine, Queens University, Kingston, ON K7L 3N6, Canada

11. Hamilton Health Sciences Centre, Hamilton, ON L9C 1C4, Canada

12. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada

13. Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada

14. Nova Scotia Health Authority, Halifax, NS B3H 2E2, Canada

15. Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada

16. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R7, Canada

17. Hopital Maisonneuve-Rosemont, Montreal, QC H1T 2M4, Canada

18. Lady Davis Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada

19. Shared Health Manitoba, Winnipeg, MB R3A 1R9, Canada

20. William Osler Health System, Brampton, ON L6R 3J7, Canada

21. CHUM—Centre Hospitalier de l’Universite de Montreal, Montreal, QC H3T 1J4, Canada

22. BC Cancer, Vancouver, BC V5Z 4S6, Canada

23. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6H 3Z6, Canada

Abstract

The detection of gene fusions by RNA-based next-generation sequencing (NGS) is an emerging method in clinical genetic laboratories for oncology biomarker testing to direct targeted therapy selections. A recent Canadian study (CANTRK study) comparing the detection of NTRK gene fusions on different NGS assays to determine subjects’ eligibility for tyrosine kinase TRK inhibitor therapy identified the need for recommendations for best practices for laboratory testing to optimize RNA-based NGS gene fusion detection. To develop consensus recommendations, representatives from 17 Canadian genetic laboratories participated in working group discussions and the completion of survey questions about RNA-based NGS. Consensus recommendations are presented for pre-analytic, analytic and reporting aspects of gene fusion detection by RNA-based NGS.

Funder

Bayer Inc.

Publisher

MDPI AG

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3