Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction-Reference-Cited by-同舟云学术

Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

Published:2023-02-06 Issue:2 Volume:30 Page:1954-1976
ISSN:1718-7729
Container-title:Current Oncology
language:en
Short-container-title:Current Oncology

Author:

Rabaan Ali A.¹²³^ORCID,AlSaihati Hajir⁴^ORCID,Bukhamsin Rehab⁵,Bakhrebah Muhammed A.⁶^ORCID,Nassar Majed S.⁶^ORCID,Alsaleh Abdulmonem A.⁷^ORCID,Alhashem Yousef N.⁷^ORCID,Bukhamseen Ammar Y.⁸,Al-Ruhimy Khalil⁹,Alotaibi Mohammed⁹,Alsubki Roua A.¹⁰^ORCID,Alahmed Hejji E.¹¹,Al-Abdulhadi Saleh¹²¹³^ORCID,Alhashem Fatemah A.¹⁴,Alqatari Ahlam A.¹⁵,Alsayyah Ahmed¹⁶,Farahat Ramadan Abdelmoez¹⁷^ORCID,Abdulal Rwaa H.¹⁸¹⁹,Al-Ahmed Ali H.²⁰,Imran Mohd.²¹^ORCID,Mohapatra Ranjan K.²²^ORCID

Affiliation:

1. Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia

2. College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia

3. Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan

4. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia

5. Dammam Regional Laboratory and Blood Bank, Dammam 31411, Saudi Arabia

6. Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia

7. Clinical Laboratory Science Department, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia

8. Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia

9. Department of Public Health, Ministry of Health, Riyadh 14235, Saudi Arabia

10. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia

11. Department of Laboratory and Blood Bank, King Fahad Hospital, Al Hofuf 36441, Saudi Arabia

12. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Riyadh 11942, Saudi Arabia

13. Saleh Office for Medical Genetic and Genetic Counseling Services, The House of Expertise, Prince Sattam Bin Abdulaziz University, Dammam 32411, Saudi Arabia

14. Laboratory Medicine Department, Hematopathology Division, King Fahad Hospital of the University, Al-Khobar 31441, Saudi Arabia

15. Hematopathology Department, Clinical Pathology, Al-Dorr Specialist Medical Center, Qatif 31911, Saudi Arabia

16. Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

17. Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh 33511, Egypt

18. Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia

19. Vaccines and Immunotherapy Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia

20. Dammam Health Network, Eastern Health Cluster, Dammam 31444, Saudi Arabia

21. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia

22. Department of Chemistry, Government College of Engineering, Keonjhar 758002, India

Abstract

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.

Publisher

MDPI AG

Link

https://www.mdpi.com/1718-7729/30/2/152/pdf

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