Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century-Reference-Cited by-同舟云学术

Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century

Published:2023-10-19 Issue:10 Volume:30 Page:9230-9243
ISSN:1718-7729
Container-title:Current Oncology
language:en
Short-container-title:Current Oncology

Author:

Mheid Sara¹,Allen Stefan²,Ng Sylvia S. W.³,Hall William A.⁴,Sanford Nina N.⁵,Aguilera Todd A.⁵,Elamir Ahmed M.⁵,Bahij Rana⁶,Intven Martijn P. W.⁷,Radhakrishna Ganesh⁸,Mohamad Issa⁹^ORCID,De Leon Jeremy¹⁰,Tan Hendrick¹¹¹²,Lewis Shirley¹³^ORCID,Gani Cihan¹⁴^ORCID,Stanecu Teo¹,Dell’Acqua Veronica¹⁵,Hosni Ali¹

Affiliation:

1. Department of Radiation Oncology, University of Toronto, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada

2. Department of Radiation Oncology, Dalhousie University, Nova Scotia Health, Halifax, NS B3H 4R2, Canada

3. Department of Radiation Oncology, University of Toronto, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada

4. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA

5. Department of Radiation Oncology, University of Texas Southwestern, Dallas, TX 75235, USA

6. Department of Oncology, Odense University Hospital, 5000 Odense, Denmark

7. Department of Radiotherapy, Division Imaging and Oncology, University Medical Centre, 3584 CX Utrecht, The Netherlands

8. Department of Radiotherapy, The Christie NHS Foundation Trust, Manchester M20 4BX, UK

9. Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan

10. GenesisCare, Alexandria, NSW 2015, Australia

11. Department of Radiation Oncology, Fiona Stanley Hospital, Perth, WA 6150, Australia

12. GenesisCare, Perth, WA 6150, Australia

13. Department of Radiotherapy and Oncology, Manipal Comprehensive Cancer Care Centre, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India

14. Department of Radiation Oncology, University Hospital Tübingen, 72076 Tübingen, Germany

15. Medical Affairs and Clinical Research, Linac-Based RT, Elekta Milan, 20864 Lombardy, Italy

Abstract

The utilization of stereotactic body radiation therapy for the treatment of liver metastasis has been widely studied and has demonstrated favorable local control outcomes. However, several predictive factors play a crucial role in the efficacy of stereotactic body radiation therapy, such as the number and size (volume) of metastatic liver lesions, the primary tumor site (histology), molecular biomarkers (e.g., KRAS and TP53 mutation), the use of systemic therapy prior to SBRT, the radiation dose, and the use of advanced technology and organ motion management during SBRT. These prognostic factors need to be considered when clinical trials are designed to evaluate the efficacy of SBRT for liver metastases.

Publisher

MDPI AG

Link

https://www.mdpi.com/1718-7729/30/10/667/pdf

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