HPV Self-Sampling for Cervical Cancer Screening in Under-Screened Saskatchewan Populations: A Pilot Study

Author:

Vink Erin1,Antaya Gabriella1ORCID,Hamula Camille2,Holinaty Carla3ORCID,Minion Jessica2,Pond Gregory R.4ORCID,McCrea Sabryna1,Dwernychuk Lynn5,Graham Holly6,Broderick Gordon7ORCID,Kinloch Mary2ORCID,Brown Broderick Jennifer8ORCID

Affiliation:

1. College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada

2. Department of Laboratory Medicine and Pathology, College of Medicine University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada

3. Department of Academic Family Medicine, University of Saskatchewan, Saskatoon, SK S7N 3Y5, Canada

4. Department of Oncology, Faculty of Health Sciences, McMaster University, Hamilton, ON L8V 5C2, Canada

5. Saskatchewan Cancer Agency, Saskatoon, SK S7N 4H4, Canada

6. Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, SK S7K 2Z4, Canada

7. Vaccine and Infectious Disease Organization (VIDO), Saskatoon, SK S7N 5E3, Canada

8. Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 4H4, Canada

Abstract

Of all cancers in female Canadians, the most rapidly increasing incidence is that of cervical cancer. The objective of this pilot study was to assess how HPV self-sampling might improve cervical cancer screening participation in both urban and rural settings in Saskatchewan, one of the most sparsely populated provinces in Canada. Study groups consisted of n = 250 participants to whom self-swabbing kits were mailed with instructions and n = 250 participants to whom kits were handed out in 6 urban and rural clinics. The inclusion criteria selected subjects aged 30–69 years who were Saskatchewan residents for at least 5 years with valid health coverage, had a cervix, and had no record of cervical cancer screening in 4 years. The returned samples were analyzed for specific HPV strains using the Roche Molecular Diagnostics Cobas 4800® System. The overall response rate was ~16%, with the response to the handout distribution being roughly double that of the mailout. While HPV positivity did not differ across the distribution groups, participants at a specific inner-city clinic reported significantly higher positivity to at least one HPV strain as compared to any other clinic and all mailouts combined. For this high-risk population, in-person handout of self-sampling kits may be the most effective means of improving screening.

Funder

Women Leading Philanthropy Royal University Hospital Foundation

an investigator-initiated study grant from Roche Diagnostics

Publisher

MDPI AG

Reference17 articles.

1. Projected estimates of cancer in Canada in 2024;Brenner;Can. Med. Assoc. J.,2024

2. Projected estimates of cancer in Canada in 2020;Brenner;Can. Med. Assoc. J.,2020

3. (2022, September 01). Screening Program for Cervical Cancer. Available online: https://saskcancer.ca/prevention-screening/screening/screening-program-cervical-cancer.

4. Canadian Partnership Against Cancer (2024, February 03). Cervical Cancer Screening in Canada: Monitoring & Evaluation of Quality Indicators. Toronto. Available online: https://s22457.pcdn.co/wp-content/uploads/2019/01/Cervical-Cancer-Screen-Quality-Indicators-Report-2016-EN.pdf.

5. Perceived barriers to cervical cancer screening and motivators for at-home human papillomavirus self-sampling during the COVID-19 pandemic: Results from a telephone survey;Parker;eLife,2023

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