Does Prior Respiratory Viral Infection Provide Cross-Protection Against Subsequent Respiratory Viral Infections? A Systematic Review and Meta-Analysis

Author:

Gopal Vennila12,Koh Matthew Chung Yi3ORCID,Ngiam Jinghao Nicholas3ORCID,Hang-Cheng Ong4,Somani Jyoti13,Tambyah Paul Anatharajah13ORCID,Tey Jeremy15

Affiliation:

1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore

2. Faculty of Medicine and Health Sciences, University Malaysia Sabah, Kota Kinabalu 88400, Malaysia

3. Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore 119228, Singapore

4. Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia

5. Department of Radiation Oncology, National University Cancer Institute, Singapore 119074, Singapore

Abstract

The epidemiology of different respiratory viral infections is believed to be affected by prior viral infections in addition to seasonal effects. This PROSPERO-registered systematic review identified 7388 studies, of which six met our criteria to answer the question specifically. The purpose of this review was to compare the prevalence of sequential viral infections in those with previously documented positive versus negative swabs. The pooled prevalence of sequential viral infections over varying periods from 30–1000 days of follow-up was higher following a negative respiratory viral swab at 0.15 than following a positive swab at 0.08, indicating the potential protective effects of prior respiratory viral infections. However, significant heterogeneity and publication biases were noted. There is some evidence, albeit of low quality, of a possible protective effect of an initial viral infection against subsequent infections by a different virus, which is possibly due to broad, nonspecific innate immunity. Future prospective studies are needed to validate our findings.

Funder

Singapore Ministry of Health National Medical Research Council grant to Integrated Innovations in Infectious Diseases

ingapore Ministry of Health National Medical Research Council Clinician Investigator Salary Support Programme

Publisher

MDPI AG

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