Biological Scaffolds Assembled with Magnetic Nanoparticles for Bone Tissue Engineering: A Review

Author:

Li Zheng1,Xue Le1,Wang Peng1,Ren Xueqian2,Zhang Yunyang3,Wang Chuan4,Sun Jianfei1ORCID

Affiliation:

1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, School of Bioscience and Medical Engineering, Southeast University, Nanjing 210009, China

2. Clinical Medical Engineering Department, The Affiliated Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China

3. Center of Modern Analysis, Nanjing University, Nanjing 210000, China

4. Naval Medical Center of PLA, Naval Medical University (Second Military Medical University), Shanghai 200433, China

Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are widely used in bone tissue engineering because of their unique physical and chemical properties and their excellent biocompatibility. Under the action of a magnetic field, SPIONs loaded in a biological scaffold can effectively promote osteoblast proliferation, differentiation, angiogenesis, and so on. SPIONs have very broad application prospects in bone repair, bone reconstruction, bone regeneration, and other fields. In this paper, several methods for forming biological scaffolds via the biological assembly of SPIONs are reviewed, and the specific applications of these biological scaffolds in bone tissue engineering are discussed.

Publisher

MDPI AG

Subject

General Materials Science

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