Affiliation:
1. Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland
Abstract
The number of children suffering from cardiovascular diseases (CVDs) is rising globally. Therefore, there is an urgent need to acquire a better understanding of the genetic factors and molecular mechanisms related to the pathogenesis of CVDs in order to develop new prevention and treatment strategies for the future. MicroRNAs (miRNAs) constitute a class of small non-coding RNA fragments that range from 17 to 25 nucleotides in length and play an essential role in regulating gene expression, controlling an abundance of biological aspects of cell life, such as proliferation, differentiation, and apoptosis, thus affecting immune response, stem cell growth, ageing and haematopoiesis. In recent years, the concept of miRNAs as diagnostic markers allowing discrimination between healthy individuals and those affected by CVDs entered the purview of academic debate. In this review, we aimed to systematise available information regarding miRNAs associated with arrhythmias, cardiomyopathies, myocarditis and congenital heart diseases in children. We focused on the targeted genes and metabolic pathways influenced by those particular miRNAs, and finally, tried to determine the future of miRNAs as novel biomarkers of CVD.
Funder
Medical University of Bialystok
Reference165 articles.
1. (2020, December 09). The Top 10 Causes of Death. Available online: https://www.Who.Int/News-Room/Fact-Sheets/Detail/The-Top-10-Causes-Of-Death?Fbclid=Iwar2llcq33xsxbhssptiozzuynislhja4oroomf3cqs-Svkzfutpy20x7heo.
2. The C. elegans Heterochronic Gene Lin-4 Encodes Small RNAs with Antisense Complementarity to Lin-14;Lee;Cell,1993
3. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation;Hayder;Front. Endocrinol.,2018
4. Tastsoglou, S., Miliotis, M., Kavakiotis, I., Alexiou, A., Gkotsi, E.C., Lambropoulou, A., Lygnos, V., Kotsira, V., Maroulis, V., and Zisis, D. (2021). Plasmir: A Manual Collection of Circulating Micrornas of Prognostic and Diagnostic Value. Cancers, 13.
5. MiRNA Activation Is an Endogenous Gene Expression Pathway;Vaschetto;RNA Biol.,2018