Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling

Author:

Shao Jiahao1,Jiang Genglong1ORCID,Li Yanhong1,Wang Meigui1,Tang Tao1,Wang Jie1ORCID,Jia Xianbo1ORCID,Lai Songjia1ORCID

Affiliation:

1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Abstract

Recently, the trend of obesity is becoming increasingly prevalent, and the underlying pathogenesis of obesity is complex and needs to be researched further. In this study, we report a decreased expression of let-7a-5p in the white adipose tissue (WAT) of animals with obesity. Using the RNA oligo, let-7a-5p over-expression or suppression–expression is achieved, impacting the proliferation and differentiation of preadipocytes in vitro. Srebf2 mechanistically interacts with the metabolic effect of let-7a-5p and participates in lipid accumulation by regulating Srebf2 downstream signaling. Moreover, let-7a-5p binds to Thbs1 to interact with the PI3K-AKT-mTOR pathway, down-regulating the phosphorylation levels of AKT, mTOR, and S6K1 to decrease lipid accumulation. In conclusion, our study highlights the physiological significance of let-7a-5p in lipid accumulation and suggests that the let-7a-5p/Srebf2 and let-7a-5p/Thbs1/PI3K-AKT-mTOR axes may represent potential mechanisms for controlling lipid accumulation in obesity.

Funder

National Modern Agricultural Industrial Technology System

Key Research and Development Program of Sichuan Province

Publisher

MDPI AG

Reference38 articles.

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