Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica-Reference-Cited by-同舟云学术

Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica

Published:2024-01-08 Issue:2 Volume:25 Page:775
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Lee Yun-Seong¹,Ji Byeong-Jun²³^ORCID,Pae Hyun-Ock¹,Cheon Mu-Weon⁴,Xu Guangpeng⁵,Chun Hyun-Soo²,Kim Sooah⁵

Affiliation:

1. Department of Microbiology and Immunology, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea

2. HumanEnos LLC., Wanju 55347, Republic of Korea

3. Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju 54907, Republic of Korea

4. Department of Chemistry, KwangWoon University, Seoul 01897, Republic of Korea

5. Department of Environment Science & Biotechnology, Jeonju University, Jeonju 55069, Republic of Korea

Abstract

The aim of this study was to evaluate the anti-inflammatory effect of fermented cabbage extract (FC) containing nitric oxide metabolites with silica (FCS) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD) in BALB/c mice. Atopic dermatitis-like allergic contact dermatitis was induced by DNFB challenge in the ear after DNFB sensitization on the dorsal skin of mice. FCS alleviated the severity of atopic dermatitis-like skin lesions. In addition, epidermis thickness of the ear and penetration of inflammatory cells in atopic dermatitis-like skin lesions were decreased after topical application of FCS. The serum levels of TNF-α and IL-4 were measured in atopic dermatitis mice using ELISA kits, which were observed to be significantly decreased after topical application of FCS. This study demonstrates that the FCS can be used as a potential therapeutic for the treatment and prevention of AD.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/25/2/775/pdf

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