Testing and Visualization of Associations in Three-Way Contingency Tables: A Study of the Gender Gap in Patients with Type 1 Diabetes and Cardiovascular Complications

Author:

Lombardo Rosaria1ORCID,Beh Eric J.23ORCID,Prattichizzo Francesco4,Lucisano Giuseppe5,Nicolucci Antonio5,Eliasson Björn6ORCID,Carlsen Hanne Krage7ORCID,Grotta Rosalba La4ORCID,Pellegrini Valeria4ORCID,Ceriello Antonio4ORCID

Affiliation:

1. Department of Economics, University of Campania “Luigi Vanvitelli”, 81043 Capua (CE), Italy

2. National Institute for Applied Statistics Research Australia (NIASRA), University of Wollongong, Wollongong, NSW 2522, Australia

3. Centre for Multi-Dimensional Data Visualisation (MuViSU), Stellenbosch University, Stellenbosch 7602, South Africa

4. IRCCS MultiMedica, 20138 Milan, Italy

5. CORESEARCH, Center for Outcomes Research and Clinical Epidemiology, 65122 Pescara, Italy

6. Department of Medicine, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden

7. Center of Registers in Region Västra Götaland, 413 45 Gothenburg, Sweden

Abstract

Using data from the Swedish National Diabetes Register, this study examines the gender disparity among patients with type 1 diabetes who have experienced a specific cardiovascular complication, while exploring the association between their weight variability, age group, and gender. Fourteen cardiovascular complications have been considered. This analysis is conducted using three-way correspondence analysis (CA), which allows for the partitioning and decomposition of Pearson’s three-way chi-squared statistic. The dataset comprises information organized in a data cube, detailing how weight variability among these patients correlates with a cardiovascular complication, age group, and gender. The three-way CA method presented in this paper allows one to assess the statistical significance of the association between these variables and to visualize this association, highlighting the gender gap among these patients. From this analysis, we find that the association between weight variability, age group, and gender varies among different types of cardiovascular complications.

Funder

PRIN-2022 SciK-Health: Mapping Scientific Knowledge about Health for Decision-making

PRIN-2022 PNRR “The value of scientific production for patient care in A. H. S. C.”

Publisher

MDPI AG

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