New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696

Author:

Zhuravleva Olesya I.ORCID,Oleinikova Galina K.,Antonov Alexandr S.,Kirichuk Natalia N.,Pelageev Dmitry N.ORCID,Rasin Anton B.,Menshov Alexander S.,Popov Roman S.,Kim Natalya Yu.,Chingizova Ekaterina A.,Chingizov Artur R.,Volchkova Olga O.,von Amsberg Gunhild,Dyshlovoy Sergey A.ORCID,Yurchenko Ekaterina A.ORCID,Guzhova Irina V.,Yurchenko Anton N.ORCID

Abstract

Six new polyketides acrucipentyns A–F (1–6) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher’s method and ROESY data analysis. Acrucipentyns A–E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A–F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of Staphylococcus aureus and decreased LDH release from human keratinocytes HaCaT in S. aureus skin infection in an in vitro model.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Plant Science,Ecology, Evolution, Behavior and Systematics,Microbiology (medical)

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