Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

Author:

Nguyen Khoa D.12,Amerio Andrea34ORCID,Aguglia Andrea34ORCID,Magnani Luca5ORCID,Parise Alberto6,Conio Benedetta34,Serafini Gianluca34ORCID,Amore Mario34,Costanza Alessandra789

Affiliation:

1. Department of Microbiology and Immunology, Stanford University, Palo Alto, CA 94305, USA

2. Tranquis Therapeutics, Palo Alto, CA 94065, USA

3. Section of Psychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16126 Genoa, Italy

4. IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy

5. Department of Psychiatry, San Maurizio Hospital of Bolzano, 39100 Bolzano, Italy

6. Geriatric-Rehabilitation Department, University Hospital of Parma, 43126 Parma, Italy

7. Department of Psychiatry, Adult Psychiatry Service, University Hospitals of Geneva (HUG), 1207 Geneva, Switzerland

8. Department of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), 6900 Lugano, Switzerland

9. Department of Psychiatry, Faculty of Medicine, University of Geneva (UNIGE), 1211 Geneva, Switzerland

Abstract

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.

Publisher

MDPI AG

Subject

General Medicine

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