Adjuvant Properties of Caffeic Acid in Cancer Treatment
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Published:2024-07-11
Issue:14
Volume:25
Page:7631
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Cortez Nicole1, Villegas Cecilia1ORCID, Burgos Viviana2, Cabrera-Pardo Jaime R.3, Ortiz Leandro4ORCID, González-Chavarría Iván5ORCID, Nchiozem-Ngnitedem Vaderament-A.6ORCID, Paz Cristian1ORCID
Affiliation:
1. Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, Chile 2. Departamento de Ciencias Biológicas y Químicas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Rudecindo Ortega, Temuco 4780000, Chile 3. Laboratorio de Química Aplicada y Sustentable (LabQAS), Departamento de Química, Facultad de Ciencias, Universidad del Bío-Bío, Concepción 4081112, Chile 4. Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5110566, Chile 5. Departamento de Fisiopatología, Facultad de Ciencias Biológicas Universidad de Concepción, Concepción 4030000, Chile 6. Institut für Chemie, Universität Potsdam, D-14476 Potsdam, Germany
Abstract
Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK1/2, thereby reducing inflammatory responses, and activating the Nrf2/ARE pathway to enhance antioxidant cell defenses. The consumption of CA has been linked to a reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. This suggests that CA could serve as a useful adjunct in cancer treatment. Studies have shown CA to be generally safe, with few adverse effects (such as back pain and headaches) reported. This review collates the latest information from Google Scholar, PubMed, the Phenol-Explorer database, and ClinicalTrials.gov, incorporating a total of 154 articles, to underscore the potential of CA in cancer prevention and overcoming chemoresistance.
Reference154 articles.
1. Heinrich Hlasiwetz (1825–1875);Kohn;J. Chem. Educ.,1945 2. Kiokias, S., Proestos, C., and Oreopoulou, V. (2020). Phenolic Acids of Plant Origin-A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties. Foods, 9. 3. Dias, M.C., Pinto, D., and Silva, A.M.S. (2021). Plant Flavonoids: Chemical Characteristics and Biological Activity. Molecules, 26. 4. Tzanova, M., Atanasov, V., Yaneva, Z., Ivanova, D., and Dinev, T. (2020). Selectivity of current extraction techniques for flavonoids from plant materials. Processes, 8. 5. Bule, M., Khan, F., Nisar, M.F., Niaz, K., Nabavi, S., Saeedi, M., and Sanches Silva, A. (2020). Tannins (hydrolysable tannins, condensed tannins, phlorotannins, flavono-ellagitannins). Recent Advances in Natural Products Analysis, Elsevier.
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