A Bioinformatic Assay of Quercetin in Gastric Cancer

Author:

Zúñiga-Hernández Sergio Raúl1ORCID,García-Iglesias Trinidad2ORCID,Macías-Carballo Monserrat3ORCID,Pérez-Larios Alejandro4ORCID,Gutiérrez-Mercado Yanet Karina5,Camargo-Hernández Gabriela6,Rodríguez-Razón Christian Martín7ORCID

Affiliation:

1. Departamento de Ciencias de la Salud, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos 47620, Mexico

2. Instituto de Investigación de Cáncer en la Infancia y Adolescencia, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara 44340, Mexico

3. Laboratorio de Biociencias, Departamento de Clínicas, Centro Universitario de los Altos, Tepatitlán de Morelos 47620, Mexico

4. Laboratorio de Nanomateriales, Agua y Energia, Departamento de Ingenierias, Centro Universitario de los Altos, Tepatitlán de Morelos 47620, Mexico

5. Laboratorio Biotecnológico de Investigación y Diagnóstico, Departamento de Clínicas, Centro Universitario de los Altos, Tepatitlán de Morelos 47620, Mexico

6. Instituto de Investigación en Ciencias Médicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos 47620, Mexico

7. Laboratorio de Experimentación Animal (Bioterio), Departamento de Ciencias de la Salud, Centro Universitario de los Altos, Tepatitlán de Morelos 47620, Mexico

Abstract

Gastric cancer (GC) remains a significant global health challenge, with high mortality rates, especially in developing countries. Current treatments are invasive and have considerable risks, necessitating the exploration of safer alternatives. Quercetin (QRC), a flavonoid present in various plants and foods, has demonstrated multiple health benefits, including anticancer properties. This study investigated the therapeutic potential of QRC in the treatment of GC. We utilized advanced molecular techniques to assess the impact of QRC on GC cells, examining its effects on cellular pathways and gene expression. Our findings indicate that QRC significantly inhibits GC cell proliferation and induces apoptosis, suggesting its potential as a safer therapeutic option for GC treatment. Further research is required to validate these results and explore the clinical applications of QRC in cancer therapy.

Publisher

MDPI AG

Reference63 articles.

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2. Mukkamalla, S.K.R., Recio-Boiles, A., and Babiker, H.M. (2024, March 18). Gastric Cancer, Available online: https://www.ncbi.nlm.nih.gov/books/NBK459142/.

3. World Health Organization (2024, March 18). Global Cancer Observatory. Available online: https://gco.iarc.fr/en.

4. Cervical Cancer: Evaluation and Management;Wipperman;Am. Fam. Physician,2018

5. Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro;Encinar;Food Chem. Toxicol.,2020

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