Gut Microbiota Signatures in Colorectal Cancer as a Potential Diagnostic Biomarker in the Future: A Systematic Review

Author:

Herlo Lucian-Flavius1,Salcudean Andreea2,Sirli Roxana3,Iurciuc Stela4,Herlo Alexandra5,Nelson-Twakor Andreea6ORCID,Alexandrescu Luana7,Dumache Raluca89ORCID

Affiliation:

1. Doctoral School, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania

2. Discipline of Sociobiology, Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540136 Targu Mures, Romania

3. Advanced Regional Research Center in Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania

4. Cardiology Department, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania

5. Department XIII, Discipline of Infectious Diseases, Victor Babes University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania

6. Department of Internal Medicine, County Clinical Emergency Hospital of Constanta, 900647 Constanta, Romania

7. Department of Gastroenterology, County Clinical Emergency Hospital of Constanta, 900647 Constanta, Romania

8. Department of Forensic Medicine, Bioethics, Medical ethics and Medical Law, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania

9. Center for Ethics in Human Genetic Identifications, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania

Abstract

The gut microbiota has acquired significant attention in recent years for its potential as a diagnostic biomarker for colorectal cancer (CRC). In this literature review, we looked at the studies exploring alterations in gut microbiota composition associated with CRC, the potential mechanisms linking gut dysbiosis to CRC development, and the diagnostic approaches utilizing gut microbiota analysis. Our research has led to the conclusion that individuals with CRC often display alterations in their gut microbiota composition compared to healthy individuals. These alterations can include changes in the diversity, abundance, and type of bacteria present in the gut. While the use of gut microbiota as a diagnostic biomarker for CRC holds promise, further research is needed to validate its effectiveness and standardize testing protocols. Additionally, considerations such as variability in the microbiota composition among individuals and potential factors must be addressed before microbiota-based tests can be widely implemented in clinical practice.

Funder

Victor Babes University of Medicine and Pharmacy Timisoara

Publisher

MDPI AG

Reference65 articles.

1. Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis;Sutherland;Clin. Gastroenterol. Hepatol.,2022

2. Social determinants of colorectal cancer risk, stage, and survival: A systematic review;Coughlin;Int. J. Colorectal Dis.,2020

3. Colorectal cancer statistics, 2023;Siegel;CA Cancer J. Clin.,2023

4. Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors;Rawla;Prz. Gastroenterol.,2019

5. Changing Colorectal Cancer Trends in Asians: Epidemiology and Risk Factors;Pardamean;Oncol. Rev.,2023

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3