Abstract
Influenza A virus (IAV) infection during pregnancy disrupts maternal and fetal health through biological mechanisms, which are to date poorly characterised. During pregnancy, the viral clearance mechanisms from the lung are sub-optimal and involve hyperactive innate and adaptive immune responses that generate wide-spread inflammation. Pregnancy-related adaptations of the immune and the cardiovascular systems appear to result in delayed recovery post-viral infection, which in turn promotes a prolonged inflammatory phenotype, increasing disease severity, and causing maternal and fetal health problems. This has immediate and long-term consequences for the mother and fetus, with complications including acute cardiopulmonary distress syndrome in the mother that lead to perinatal complications such as intrauterine growth restriction (IUGR), and birth defects; cleft lip, cleft palate, neural tube defects and congenital heart defects. In addition, an increased risk of long-term neurological disorders including schizophrenia in the offspring is reported. In this review we discuss the pathophysiology of IAV infection during pregnancy and its striking similarity to other well-established complications of pregnancy such as preeclampsia. We discuss general features of vascular disease with a focus on vascular inflammation and define the “Vascular Storm” that is triggered by influenza infection during pregnancy, as a pivotal disease mechanism for short and long term cardiovascular complications.
Funder
National Health and Medical Research Council
Subject
Virology,Infectious Diseases
Reference163 articles.
1. WHO (2019). Who Launches New Global Influenza Strategy. Saudi Med. J., 40, 414.
2. The fetal origins of mental illness;Oler;Am. J. Obstet. Gynecol.,2019
3. Perivascular fat, AMP-activated protein kinase and vascular diseases;Almabrouk;J. Cereb. Blood Flow Metab.,2014
4. Adaptive immunity and atherosclerosis;Andersson;Clin. Immunol.,2010
5. Moderately pathogenic maternal influenza A virus infection disrupts placental integrity but spares the fetal brain;Antonson;Brain Behav. Immun.,2021
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