Three-Dimensional Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering

Author:

Sheikh Zeeshan123ORCID,Nayak Vasudev Vivekanand4,Daood Umer5,Kaur Anupreet6,Moussa Hanan1,Canteenwala Abbas7ORCID,Michaud Pierre-Luc2ORCID,de Fátima Balderrama Ísis89,de Oliveira Sousa Edisa810,Tovar Nick11,Torroni Andrea12,Glogauer Michael1314ORCID,Talib Huzefa11,Coelho Paulo G.415,Witek Lukasz81216ORCID

Affiliation:

1. Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, 5981 University Avenue, Halifax, NS B3H 1W2, Canada

2. Department of Dental Clinical Sciences, Faculty of Dentistry, Dalhousie University, 5981 University Avenue, Halifax, NS B3H 1W2, Canada

3. Biomedical Engineering, Faculty of Medicine, Dalhousie University, Dental Building, 5981 University Avenue, Halifax, NS B3H 3J5, Canada

4. Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA

5. School of Dentistry, International Medical University, Jln Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia

6. Faculty of Health Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond St., London, ON N6A 5C1, Canada

7. Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada

8. Biomaterials Division, NYU Dentistry, New York, NY 10010, USA

9. Department of Diagnosis and Surgery, School of Dentistry of Araraquara, Sao Paulo State University, R. Humaitá, Sao Paulo 14801-385, Brazil

10. Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of Sao Paulo, Alameda Dr. Octávio Pinheiro Brisolla, Bauru 17012-901, Brazil

11. Department of Oral and Maxillofacial Surgery, NYU Dentistry, New York, NY 10010, USA

12. Hansjörg Wyss Department of Plastic Surgery, NYU Grossman School of Medicine, New York, NY 10016, USA

13. Department of Dental Oncology, University Health Network, Princess Margaret Cancer Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada

14. Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, ON M5G 1X3, Canada

15. DeWitt Daughtry Family Department of Plastic Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA

16. Department of Biomedical Engineering, NYU Tandon School of Engineering, 6 MetroTech, Brooklyn, NY 11201, USA

Abstract

Three-dimensional printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their biocompatibility, biostability, and favorable mechanical properties. However, despite their advantages, bioceramic implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, and an increased risk of implant failure. To address these challenges, researchers have been developing strategies to improve the biological performance of 3D-printed bioceramic implants. The purpose of this review is to provide an overview of 3DP techniques and strategies for bioceramic materials designed for bone regeneration. The review also addresses the use and incorporation of active biomolecules in 3D-printed bioceramic constructs to stimulate bone regeneration. By controlling the surface roughness and chemical composition of the implant, the construct can be tailored to promote osseointegration and reduce the risk of adverse tissue reactions. Additionally, growth factors, such as bone morphogenic proteins (rhBMP-2) and pharmacologic agent (dipyridamole), can be incorporated to promote the growth of new bone tissue. Incorporating porosity into bioceramic constructs can improve bone tissue formation and the overall biological response of the implant. As such, employing surface modification, combining with other materials, and incorporating the 3DP workflow can lead to better patient healing outcomes.

Publisher

MDPI AG

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