Abstract
As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in the modulation of viral infection. Consequently, viral infection and associated pathogenesis have been associated with altered LY6E gene expression. The interaction between viruses and the host immune system has offered insights into the biology of LY6E. In this review, we summarize the current knowledge of LY6E in the context of viral infection, particularly viral entry.
Funder
National Institutes of Health
Subject
Virology,Infectious Diseases
Reference50 articles.
1. Thymic shared antigen-1. A novel thymocyte marker discriminating immature from mature thymocyte subsets;Godfrey;J. Immunol.,1992
2. Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development;MacNeil;J. Immunol.,1993
3. Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell surface proteins.
4. Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family;Capone;J. Immunol.,1996
5. RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.
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