Two New Sesquiterpenoids and a New Shikimic Acid Metabolite from Mangrove Sediment-Derived Fungus Roussoella sp. SCSIO 41427
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Published:2024-02-23
Issue:3
Volume:22
Page:103
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ISSN:1660-3397
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Container-title:Marine Drugs
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language:en
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Short-container-title:Marine Drugs
Author:
Xiao Zimin1, Cai Jian2, Chen Ting3, Wang Yilin3ORCID, Chen Yixin1, Zhu Yongyan1, Chen Chunmei2, Yang Bin2ORCID, Zhou Xuefeng2ORCID, Tao Huaming1ORCID
Affiliation:
1. Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China 2. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 3. School of Stomatology, Southern Medical University, Guangzhou 510515, China
Abstract
Two new sesquiterpenoid derivatives, elgonenes M (1) and N (2), and a new shikimic acid metabolite, methyl 5-O-acetyl-5-epi-shikimate (3), were isolated from the mangrove sediment-derived fungus Roussoella sp. SCSIO 41427 together with fourteen known compounds (4–17). The planar structures were elucidated through nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. The relative configurations of 1–3 were ascertained by NOESY experiments, while their absolute configurations were determined by electronic circular dichroism (ECD) calculation. Elgonene M (1) exhibited inhibition of interleukin-1β (IL-1β) mRNA, a pro-inflammatory cytokine, at a concentration of 5 μM, with an inhibitory ratio of 31.14%. On the other hand, elgonene N (2) demonstrated inhibition at a concentration of 20 μM, with inhibitory ratios of 27.57%.
Funder
Key-Area Research and Development Program of Guangdong Province Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province Natural Science Foundation of Guangdong Province Postdoctoral Fellowship Program of CPSF
Reference28 articles.
1. Sun, Y., Chen, P., Zhai, B., Zhang, M., Xiang, Y., Fang, J., Xu, S., Gao, Y., Chen, X., and Sui, X. (2020). The Emerging Role of Ferroptosis in Inflammation. Biomed. Pharmacother., 127. 2. Coxib and traditional NSAID Trialists’ (CNT) Collaboration, Bhala, N., Emberson, J., Merhi, A., Abramson, S., Arber, N., Baron, J.A., Bombardier, C., Cannon, C., and Farkouh, M.E. (2013). Vascular and Upper Gastrointestinal Effects of Non-Steroidal Anti-Inflammatory Drugs: Meta-Analyses of Individual Participant Data from Randomised Trials. Lancet, 382, 769–779. 3. Marine Natural Products;Carroll;Nat. Prod. Rep.,2023 4. Natural Products from Mangrove Sediments-Derived Microbes: Structural Diversity, Bioactivities, Biosynthesis, and Total Synthesis;Li;Eur. J. Med. Chem.,2022 5. The Past, Present and Future of Secondary Metabolite Research in the Dothideomycetes;Chooi;Mol. Plant Pathol.,2015
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