Affiliation:
1. School of Life Science and Engineering, Foshan University, Foshan 528231, China
2. Gladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USA
Abstract
Porcine reproductive and respiratory syndrome (PRRS) is an acute, febrile, and highly contagious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). Glycoprotein 5 (GP5) is a glycosylated envelope protein encoded by the PRRSV ORF5, which has good immunogenicity and can induce the body to produce neutralizing antibodies. Therefore, study of GP5 protein is of great significance in the diagnosis, prevention, and control of PRRSV and the development of new vaccines. We reviewed GP5 protein genetic variation, immune function, interaction with viral protein and host proteins, induction of cell apoptosis, and stimulation of neutralizing antibodies. GP5 protein’s influence on virus replication and virulence, as well as its use as a target for viral detection and immunization are reviewed.
Funder
National Natural Science Foundation of China
Guangdong Science and Technology Program Project
Guangdong Basic and Applied Basic Research Foundation
Subject
General Veterinary,Animal Science and Zoology
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