Probiotics Function in Preventing Atopic Dermatitis in Children

Author:

Anania Caterina,Brindisi GiuliaORCID,Martinelli Ivana,Bonucci Edoardo,D’Orsi Miriam,Ialongo Sara,Nyffenegger AnnaORCID,Raso Tonia,Spatuzzo Mattia,De Castro Giovanna,Zicari Anna Maria,Carraro Carlo,Piccioni Maria Grazia,Olivero Francesca

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by relapsing eczematous injuries and severe pruritus. In the last few years, the AD prevalence has been increasing, reaching 20% in children and 10% in adults in high-income countries. Recently, the potential role of probiotics in AD prevention has generated considerable interest. As many clinical studies show, the gut microbiota is able to modulate systemic inflammatory and immune responses influencing the development of sensitization and allergy. Probiotics are used increasingly against AD. However, the molecular mechanisms underlying the probiotics mediated anti-allergic effect remain unclear and there is controversy about their efficacy. In this narrative review, we examine the actual evidence on the effect of probiotic supplementation for AD prevention in the pediatric population, discussing also the potential biological mechanisms of action in this regard.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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