Emerging Therapeutic Options for Refractory Pulmonary Sarcoidosis: The Evidence and Proposed Mechanisms of Action
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Published:2023-12-19
Issue:1
Volume:13
Page:15
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Nelson Nathaniel C.1, Kogan Rebecca1, Condos Rany1, Hena Kerry M.1
Affiliation:
1. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University, 301 E 17th St Suite 550, New York, NY 10003, USA
Abstract
Sarcoidosis is a systemic disease with heterogenous clinical phenotypes characterized by non-necrotizing granuloma formation in affected organs. Most disease either remits spontaneously or responds to corticosteroids and second-line disease-modifying therapies. These medications are associated with numerous toxicities that can significantly impact patient quality-of-life and often limit their long-term use. Additionally, a minority of patients experience chronic, progressive disease that proves refractory to standard treatments. To date, there are limited data to guide the selection of alternative third-line medications for these patients. This review will outline the pathobiological rationale behind current and emerging therapeutic agents for refractory or drug-intolerant sarcoidosis and summarize the existing clinical evidence in support of their use.
Reference146 articles.
1. Sève, P., Pacheco, Y., Durupt, F., Jamilloux, Y., Gerfaud-Valentin, M., Isaac, S., Boussel, L., Calender, A., Androdias, G., and Valeyre, D. (2021). Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis. Cells, 10. 2. Management of Advanced Pulmonary Sarcoidosis;Gupta;Am. J. Respir. Crit. Care Med.,2022 3. Sarcoidosis is a Th1/Th17 multisystem disorder;Facco;Thorax,2011 4. Granuloma Formation in Pulmonary Sarcoidosis;Broos;Front. Immunol.,2013 5. Tana, C., Donatiello, I., Caputo, A., Tana, M., Naccarelli, T., Mantini, C., Ricci, F., Ticinesi, A., Meschi, T., and Cipollone, F. (2021). Clinical Features, Histopathology and Differential Diagnosis of Sarcoidosis. Cells, 11.
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