Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke-Reference-Cited by-同舟云学术

Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke

Published:2021-12-08 Issue:12 Volume:9 Page:342
ISSN:2305-6304
Container-title:Toxics
language:en
Short-container-title:Toxics

Author:

Vokina Vera A.^ORCID,Sosedova Larisa M.,Novikov Mikhail A.^ORCID,Rukavishnikov Viktor S.,Kapustina Ekaterina A.,Alekseenko Anton N.,Andreeva Elizaveta S.

Abstract

The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation.

Funder

Ministry of Science and Higher Education

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.mdpi.com/2305-6304/9/12/342/pdf

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