Challenges of a Patient with Thromboembolism

Author:

Oancea Andra12ORCID,Maștaleru Alexandra12ORCID,Abdulan Irina Mihaela12,Costache Alexandru Dan12ORCID,Zota Mădălina Ioana12ORCID,Negru Robert12,Moisă Ștefana3ORCID,Trandafir Laura Mihaela3,Leon Maria Magdalena12

Affiliation:

1. Department of Medical Specialties I, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

2. Clinical Rehabilitation Hospital, 700661 Iasi, Romania

3. Department of Mother and Child, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

Abstract

Background: FV Leiden is an autosomal dominant disease, representing one of the most prevalent genetic causes for hereditary thrombophilia manifested by venous thromboembolism. Methods: We report a case of a 30-year-old patient who was admitted for enrollment in phase II cardiac rehabilitation. The cardiovascular disease onset was five years ago when the patient was diagnosed with superficial vein thrombosis, for which anticoagulant treatment was recommended. However, he discontinued the prescribed treatment independently, which resulted in the development of deep vein thrombosis. A screening for risk factors associated with venous thromboembolism was conducted, leading to the identification of a heterozygous mutation of factor V Leiden. Later, the patient was hospitalized for acute coronary syndrome necessitating stent implantation. Following this procedure, the patient started a cardiac rehabilitation program, where the patient received multidisciplinary counseling. Conclusions: At the end of the cardiac rehab, significant improvements were observed in clinical and hemodynamic parameters. Consequently, the patient was advised to continue rehabilitation treatment in the outpatient setting. Also, for patients with suboptimal maintenance of the therapeutic range of INR, the use of apixaban might be considered. Furthermore, the utilization of a reduced dosage of apixaban has demonstrated its effectiveness in preventing further venous thromboembolism.

Publisher

MDPI AG

Subject

General Earth and Planetary Sciences,Water Science and Technology,Geography, Planning and Development

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