A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with Klippel–Trenaunay Syndrome

Author:

Vocca Cristina1,Marcianò Gianmarco1,Rania Vincenzo1ORCID,Catarisano Luca1,Palleria Caterina1,Ciranni Salvatore2,Torcia Giuseppina2,Serra Raffaele2ORCID,Monea Francesco3,Spaziano Giuseppe4ORCID,De Sarro Giovambattista13ORCID,Citraro Rita13ORCID,Gallelli Luca135ORCID

Affiliation:

1. Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy

2. Vascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, Italy

3. Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy

4. Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy

5. Medifarmagen Srl, Spin Off—University of Catanzaro and Mater Domini Hospital, 88100 Catanzaro, Italy

Abstract

Klippel–Trenanauy syndrome (KTS) is a rare genetic disease determined by overexpression of the phosphatidylinositol-4-5-bisphosphate 3 kinase catalytic subunit (PIK3CA) gene. The clinical presentation is characterized by venous and capillary malformations and lymphatic malformation. To date, no definitive treatment has been suggested in order to improve the clinical symptoms related to the developments of a skin wound. In this case, we describe a young man with KTS that developed a severe skin wound in the lower right limb unresponsive to the common treatment but responsive to a treatment with oxygen-ozone therapy, pulsed magnetic fields (diamagnetic treatment), and topical fixed association of cocum caprylate, oleic acid, quercetin, and 18-β glycyrrhetinic acid. This is the first case that supports a multistep approach to treat a rare and severe disease, and we hope that other studies can support our data.

Publisher

MDPI AG

Subject

General Earth and Planetary Sciences,Water Science and Technology,Geography, Planning and Development

Reference44 articles.

1. Naganathan, S., and Tadi, P. (2023, February 25). Klippel Trenaunay Weber Syndrome, Available online: https://www.ncbi.nlm.nih.gov/books/NBK558989/?report=printable.

2. A Rare Case of Klippel-Trénaunay Syndrome;Arasu;Cureus,2022

3. International Society for the Study of Vascular Anomalies (ISSVA) classification for vascular anomalies;Darrow;Curr. Probl. Diagn. Radiol.,2019

4. Klippel-Trenaunay syndrome belongs to the PIK3CA-related overgrowth spectrum (PROS);Vahidnezhad;Exp. Dermatol.,2016

5. Klippel-Trenaunay Syndrome;John;Tech. Vasc. Interv. Radiol.,2019

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