Affiliation:
1. Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing 400715, China
Abstract
Starvation imposes significant stress on animal survival and development, resulting in organ damage within the organism. The brain, being one of the most vital organs in animals, plays a crucial role in coordinating the physiological functions of other organs. However, performing brain experiments on the human body is challenging. In this work, we selected the silkworm, a model Lepidoptera organism, due to its favorable characteristics. A comprehensive transcriptome analysis was conducted on the brain of silkworm subjected to starvation treatment. The analysis of differentially expressed genes revealed significant alterations in 330 genes following the period of starvation. Through an enrichment analysis, we successfully identified pathways associated with metabolism, hormones, immunity, and diseases. Our findings highlight the transcriptional response of the brain to starvation, providing valuable insights for comprehending the impact of starvation stress in other animals.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Chongqing Natural Science Foundation Postdoctoral Program