Affiliation:
1. Florida Medical Entomology Laboratory 200 9th St. S.E., Entomology and Nematology Department, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL 32962, USA
Abstract
The Zika virus pandemic of 2015, with mosquitoes Aedes aegypti and Ae. albopictus as the putative vectors, prompted public health concerns and the need to improve our understanding of both the horizontal and vertical transmission of Zika virus. Local transmission is especially concerning for Florida, where these two mosquito species are abundant and widespread throughout much of the year. Here, we evaluate the relative vertical transmission and filial infection rate of progeny of Florida Ae. aegypti and Ae. albopictus following ingestion of infected blood by parental mosquitoes at either 6 or 7 log10 plaque forming units/mL of Zika virus. Florida Ae. aegypti exhibited higher rates of disseminated infection than Ae. albopictus, consistent with other studies indicating greater permissibility of Zika virus in Ae. aegypti. We observed low vertical transmission in both Ae. aegypti (1.1–3.2%) and Ae. albopictus (0–0.3%) mosquitoes, despite imbibing infected blood at titers that yielded high susceptibility to infection and modest horizontal transmission rates. Filial infection rates, testing individual mosquitoes for Ae. aegypti and Ae. albopictus, were 6–10% and 0–6.4%, respectively. Both these invasive Stegomyia mosquitoes were capable of vertically transmitting Zika virus under laboratory conditions, and approximately 5% of female progeny of Ae. aegypti were capable of transmitting Zika virus upon first bite.
Funder
Florida Department of Agriculture and Consumer Services
Reference22 articles.
1. Weger-Lucarelli, J., Carrau, L., Levi, L.I., Rezelj, V., Vallet, T., Blanc, H., Boussier, J., Megrian, D., Coutermarsh-Ott, S., and LeRoith, T. (2019). Host nutritional status affects alphavirus virulence, transmission, and evolution. PLoS Pathog., 15.
2. Infection rate of Aedes aegypti mosquitoes with dengue virus depends on the interaction between temperature and mosquito genotype;Armstrong;Proc. Biol. Sci.,2017
3. Experimental transmission of Zika virus by mosquitoes from central Europe;Heitmann;Euro. Surveill.,2017
4. Florida Aedes aegypti (Diptera: Culicidae) and Ae. albopictus vector competency for Zika virus;Zimler;J. Med. Entomol.,2019
5. Vertical transmission of Zika virus in Aedes aegypti mosquitoes;Thangamani;Am. J. Trop. Med. Hyg.,2016
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