Contact Lens-Based Microchannel Rings for Detecting Ocular Hypertension

Abstract

Glaucoma is a major cause of irreversible blindness worldwide. The most acknowledged biomarker to diagnose and monitor glaucoma progression is intraocular pressure (IOP). Gold standard techniques for IOP monitoring are invasive, uncomfortable, and require visiting a clinic. In addition, most methods only provide a single snapshot on widely varying parameters. On the other hand, contact lenses have attracted particular interest to be used as continuous monitoring platforms to incorporate sensors, drugs, and more. Here, commercial contact lenses were laser-processed to be capable of detecting IOP variations in the physiological range. Three ring-couples with interspaces of 1.0, 1.5, and 2.0 mm were engraved on three soft contact lenses separately by using a carbon dioxide laser. The IOP/pressure variations induced repeatable changes in the ring-couple interspace which acted as a smartphone-readable pressure sensor. The processed contact lenses may be a potential candidate toward IOP monitoring at point-of-care settings.