Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020
Author:
Krug Catarina12ORCID, Rigaud Emma3, Siby-Diakite Dieyenaba4ORCID, Bénézet Laetitia1, Papadopoulos Pavlos4ORCID, de Valk Henriette1, Deffontaines Gaëtan3ORCID, Septfons Alexandra1, Reynes Jean-Marc4
Affiliation:
1. Santé Publique France, 94410 Saint-Maurice, France 2. European Centre for Disease Prevention and Control (ECDC), 169 73 Solna, Sweden 3. Caisse Centrale de la Mutualité Sociale Agricole, 93000 Bobigny, France 4. Institut Pasteur, Université Paris Cité, 75015 Paris, France
Abstract
We aimed to estimate the seroprevalence of Puumala orthohantavirus (PUUV) among forestry workers in northern France, and to explore sociodemographic risk factors. We conducted a random cross-sectional seroprevalence survey among 1777 forestry workers in 2019–2020. The presence of immunoglobulin G against PUUV antigens in serum was assessed using enzyme-linked immunosorbent assay and confirmed using immunofluorescence assay. Poisson regression models were used to explore factors associated with seropositivity. Weighted seroprevalence was 5% (3–6) in northeastern France, 4% (2–6) in north central France, and 1% in two regions located in the center of the country (Auvergne and Limousin). There were no seropositive workers detected in northwestern France. Seropositivity was associated with age, sex, and cumulative seniority in the forestry sector. Seroprevalence was highest in known endemic areas of the northeast and lowest in the northwest. Nevertheless, we found serological evidence of PUUV infection in two regions located in the center of the country, suggesting circulation of the virus in these regions, previously thought to be non-endemic.
Funder
Caisse Centrale de la Mutualité Sociale Agricole French Agency for Food, Environmental and Occupational Health & Safety Santé Publique France
Subject
Virology,Infectious Diseases
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