Affiliation:
1. Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil
2. Socioenvironmental and Water Resources Institute, Federal Rural University of the Amazon, Belém 66077-830, Pará, Brazil
Abstract
Docosahexaenoic acid (DHA), also known as omega-3 (n-3) polyunsaturated fatty acid (PUFA), is a natural compound that has demonstrated pharmacological activity against several malignant neoplasms. Available cancer treatments cause side effects, affect healthy cells, reduce the quality of life of patients and may cause resistance to antineoplastics. For these reasons, the search for new therapies is continuous. This narrative review aimed to compile information on in vitro experiments that study the cytotoxic effect of DHA or molecules derived from DHA in tumor and nontumor cells. This was performed to highlight the potential of DHA as a strategy for cancer therapy and to gather information, which will help researchers plan experimental designs and develop research to discover effective therapies against cancer. In addition, studies were presented that demonstrate the dose of DHA that can treat patients with cancer. Thus, a search was conducted for articles on the SCOPUS and Web of Science platforms, published until 2022, that analyzed the action of DHA against breast, lung, colorectal, prostate, stomach and liver cancers. Cytotoxic effects were observed in tumor and nontumor cell lines, and these results varied with the type of cell line studied, drug concentration, incubation time and treatment combination, i.e., with DHA alone, combined with other drugs and with molecules derived from DHA. In patients with cancer, in all analyzed studies, DHA intake was associated with eicosapentaenoic acid (EPA) and/or proteins to aid chemotherapy, and with this procedure, tumor reduction, chemotherapy tolerance and muscle mass gain were obtained. This work contributes to the community by demonstrating the possible applicability of DHA in the pharmaceutical area of oncological therapies.
Funder
CAPES through the project coordinated
Subject
Food Science,Nutrition and Dietetics
Reference48 articles.
1. Tumor Microenvironment: Recent Advances in Various Cancer Treatments;Wang;Eur. Rev. Med. Pharmacol. Sci.,2018
2. Instituto Nacional de Câncer José Alencar Gomes da Silva (2017). Estimativa 2018: Incidência de Câncer No Brasil, INCA.
3. Instituto Nacional de Câncer José Alencar Gomes da Silva (2019). Estimativa 2020: Incidência de Câncer No Brasil, INCA.
4. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Bray;CA Cancer J. Clin.,2018
5. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021
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