Using Type I Collagen Gel to Prevent Postoperative Intrauterine Adhesion: A Multicenter Retrospective Study

Author:

Lee Kwang Beom1,Chon Seung Joo1ORCID,Kim Sunghoon2,Kim Dae Yeon3,Park Chan Woo4ORCID,Shin So Jin5,Kim Seok Mo6,Lee Ki Hwan7,Ji Yong Il8

Affiliation:

1. Department of Obstetrics and Gynecology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Republic of Korea

2. Department of Obstetrics and Gynecology, Women’s Cancer Clinic, Institute of Women’s Life Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea

3. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Republic of Korea

4. Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul 13496, Republic of Korea

5. Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea

6. Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea

7. Department of Obstetrics and Gynecology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon 34134, Republic of Korea

8. Department of Obstetrics and Gynecology, Inje University, Haeundae Paik Hospital, Busan 48108, Republic of Korea

Abstract

We evaluated the clinical outcomes of using type 1 collagen gel after therapeutic resectoscopy; overall, 150 women aged > 20 who planned to undergo therapeutic resectoscopy were enrolled. The patients were randomly assigned to either of the anti-adhesive treatment groups: the type 1 collagen gel (Collabarrier®) (study group; N = 75) or the sodium hyaluronate and sodium carboxymethylcellulose gel group (control group; N = 75) after resectoscopy. One month after applying anti-adhesive materials, postoperative intrauterine adhesions were evaluated using second-look hysteroscopy; the incidence rate of postoperative intrauterine adhesions examined through second-look hysteroscopy showed no significant differences between the groups. There were no statistical differences between the frequency and mean scores of the type and intensity of adhesions in both groups. Finally, no significant differences in adverse events, serious adverse events, adverse device effects, and serious adverse device effects were noted between the two groups; type 1 collagen gel can be effectively and safely used in intrauterine surgery to minimize postoperative adhesions, thereby eventually decreasing the prevalence of infertility, secondary amenorrhea, and recurrent pregnancy loss in reproductive women.

Funder

Dalim Tissen Company Limited

Publisher

MDPI AG

Subject

General Medicine

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