One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules

Author:

Ríos-Lombardía Nicolás,García-Álvarez JoaquínORCID,González-Sabín JavierORCID

Abstract

During the last decade, the combination of different metal- and bio-catalyzed organic reactions in aqueous media has permitted the flourishing of a variety of one-pot asymmetric multi-catalytic reactions devoted to the construction of enantiopure and high added-value chemicals under mild reaction conditions (usually room temperature) and in the presence of air. Herein, a comprehensive account of the state-of-the-art in the development of catalytic networks by combining metallic and biological catalysts in aqueous media (the natural environment of enzymes) is presented. Among others, the combination of metal-catalyzed isomerizations, cycloadditions, hydrations, olefin metathesis, oxidations, C-C cross-coupling and hydrogenation reactions, with several biocatalyzed transformations of organic groups (enzymatic reduction, epoxidation, halogenation or ester hydrolysis), are discussed.

Funder

Ministerio de Economía y Competitividad

Gobierno del Principado de Asturias

Fundación BBVA

Publisher

MDPI AG

Subject

Physical and Theoretical Chemistry,Catalysis

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