A Novel Strategy for Glioblastoma Treatment by Natural Bioactive Molecules Showed a Highly Effective Anti-Cancer Potential

Author:

Giammona Alessandro12,Commisso Mauro23ORCID,Bonanomi Marcella1,Remedia Sofia1,Avesani Linda23ORCID,Porro Danilo12,Gaglio Daniela1,Bertoli Gloria12ORCID,Lo Dico Alessia12ORCID

Affiliation:

1. Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, 20054 Milan, Italy

2. NBFC, National Biodiversity Future Center, 90133 Palermo, Italy

3. Department of Biotechnology, University of Verona, 15, Strada Le Grazie, 37134 Verona, Italy

Abstract

Glioblastoma (GBM) is a severe form of brain tumor that has a high fatality rate. It grows aggressively and most of the time results in resistance to traditional treatments like chemo- and radiotherapy and surgery. Biodiversity, beyond representing a big resource for human well-being, provides several natural compounds that have shown great potential as anticancer drugs. Many of them are being extensively researched and significantly slow GBM progression by reducing the proliferation rate, migration, and inflammation and also by modulating oxidative stress. Here, the use of some natural compounds, such as Allium lusitanicum, Succisa pratensis, and Dianthus superbus, was explored to tackle GBM; they showed their impact on cell number reduction, which was partially given by cell cycle quiescence. Furthermore, a reduced cell migration ability was reported, accomplished by morphological cytoskeleton changes, which even highlighted a mesenchymal–epithelial transition. Furthermore, metabolic studies showed an induced cell oxidative stress modulation and a massive metabolic rearrangement. Therefore, a new therapeutic option was suggested to overcome the limitations of conventional treatments and thereby improve patient outcomes.

Funder

National Biodiversity Future Center

Italian Ministry of University and Research (MIUR)—ELIXIR-IT through the empowering project ELIXIRNextGenIT

Publisher

MDPI AG

Reference29 articles.

1. Naeem, S., Chazdon, R., Duffy, J.E., Prager, C., and Worm, B. (2016). Biodiversity and human well-being: An essential link for sustainable development. Proc. R. Soc. B Biol. Sci., 283.

2. Biodiversity and planetary health: A call for integrated action;Cena;Lancet,2024

3. Plants as a source of anti-cancer agents;Cragg;J. Ethnopharmacol.,2005

4. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019;Newman;J. Nat. Prod.,2020

5. The search for novel drugs leads for predominately antitumor therapies by utilizing mother nature’s pharmacophoric libraries;Kingston;Curr. Opin. Drug Discov. Dev.,2005

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3