Abstract
Owing to a higher demand for glucosamine (GlcN) in metabolic processes in tumor cells than in normal cells (i.e., GlcN effects), tumor imaging in magnetic resonance imaging (MRI) can be highly improved using GlcN-conjugated MRI contrast agents. Here, GlcN was conjugated with polyacrylic acid (PAA)-coated ultrasmall gadolinium oxide nanoparticles (UGONs) (davg = 1.76 nm). Higher positive (brighter or T1) contrast enhancements at various organs including tumor site were observed in human brain glioma (U87MG) tumor-bearing mice after the intravenous injection of GlcN-PAA-UGONs into their tail veins, compared with those obtained with PAA-UGONs as control, which were rapidly excreted through the bladder. Importantly, the contrast enhancements of the GlcN-PAA-UGONs with respect to those of the PAA-UGONs were the highest in the tumor site owing to GlcN effects. These results demonstrated that GlcN-PAA-UGONs can serve as excellent T1 MRI contrast agents in tumor imaging via GlcN effects.
Funder
National Research Foundation of Korea
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference57 articles.
1. Precision medicine and molecular imaging: New targeted approaches toward cancer therapeutic and diagnosis;Am. J. Nucl. Med. Mol. Imaging,2016
2. Molecular imaging for personalized cancer care;Mol. Oncol.,2012
3. Molecular magnetic resonance imaging in cancer;J. Transl. Med.,2015
4. Cancer diagnosis and treatment guidance: Role of MRI and MRI probes in the era of molecular imaging;Curr. Pharm. Biotechnol.,2013
5. An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumor sites;J. Pharm. Pharmacol.,2019
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