Maternal Dietary Deficiencies in Folic Acid and Choline Result in Larger Damage Volume, Reduced Neuro-Degeneration and -Inflammation and Changes in Choline Metabolites after Ischemic Stroke in Middle-Aged Offspring

Author:

Hurley Lauren12,Jauhal Jesse13,Ille Sharadyn3,Pull Kasey1,Malysheva Olga V.4,Jadavji Nafisa M.12567ORCID

Affiliation:

1. Biomedical Sciences Program, Midwestern University, Glendale, AZ 85308, USA

2. College of Veterinary Medicine, Midwestern University, Glendale, AZ 85308, USA

3. College of Dental Medicine of Arizona, Midwestern University, Glendale, AZ 85308, USA

4. Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA

5. College of Osteopathic Medicine, Midwestern University, Glendale, AZ 85308, USA

6. Department of Child Health, University of Arizona, Phoenix, AZ 85721, USA

7. Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada

Abstract

Maternal dietary levels of one-carbon (1C) metabolites (folic acid and choline) during pregnancy play a vital role in neurodevelopment. However, the impact of maternal dietary deficiencies on offspring stroke outcomes later in life remains undefined. The aim of this study was to investigate the role of maternal dietary deficiencies in folic acid and choline on ischemic stroke outcomes in middle-aged offspring. Female mice were maintained on either a control or deficient diet prior to and during pregnancy and lactation. At 10 months of age ischemic stroke was induced in male and female offspring. Stroke outcome was assessed by measuring motor function and brain tissue. There was no difference in offspring motor function; however, sex differences were present. In brain tissue, maternal dietary deficiency increased ischemic damage volume and offspring from deficient mothers had reduced neurodegeneration and neuroinflammation within the ischemic region. Furthermore, there were changes in plasma 1C metabolites as a result of maternal diet and sex. Our data indicate that maternal dietary deficiencies do not impact offspring behavior after ischemic stroke but do play a role in brain histology and one-carbon metabolite levels in plasma. Additionally, this study demonstrates that the sex of mice plays an important role in stroke outcomes.

Funder

American Heart Association

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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