Tripeptide-Catalyzed Asymmetric Aldol Reaction Between α-ketoesters and Acetone Under Acidic Cocatalyst-Free Conditions-Reference-Cited by-同舟云学术

Tripeptide-Catalyzed Asymmetric Aldol Reaction Between α-ketoesters and Acetone Under Acidic Cocatalyst-Free Conditions

Published:2019-06-09 Issue:6 Volume:9 Page:514
ISSN:2073-4344
Container-title:Catalysts
language:en
Short-container-title:Catalysts

Author:

Kon Kazumasa,Takai Hiromu,Kohari Yoshihito^ORCID,Murata Miki

Abstract

Here, we report the tripeptide-catalyzed asymmetric aldol reaction between α-ketoesters and acetone under acidic cocatalysts-free conditions. H-Pro-Tle-Gly-OH 3g-catalyzed reactions between α-ketoesters and acetone resulted in up to 95% yield and 88% ee. Analysis of the transition state using density functional theory (DFT) calculations revealed that the tert-butyl group in 3g played an important role in enantioselectivity.

Publisher

MDPI AG

Subject

Physical and Theoretical Chemistry,Catalysis

Link

https://www.mdpi.com/2073-4344/9/6/514/pdf

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