Pathological Effects of SARS-CoV-2 Associated with Hematological Abnormalities
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Published:2023-08-28
Issue:9
Volume:45
Page:7161-7182
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ISSN:1467-3045
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Container-title:Current Issues in Molecular Biology
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language:en
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Short-container-title:CIMB
Author:
Shama 1, Mahmood Asif12ORCID, Mehmood Shahid3, Zhang Wen1
Affiliation:
1. Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang 212013, China 2. School of Material Science and Engineering, Jiangsu University, Zhenjiang 212013, China 3. Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
Abstract
The SARS coronavirus 2 (SARS-CoV-2) is the causative agent of the 2019 coronavirus disease (COVID-19) pandemic that has claimed the lives of 6.9 million people and infected over 765 million. It has become a major worldwide health problem and is also known to cause abnormalities in various systems, including the hematologic system. COVID-19 infection primarily affects the lower respiratory tract and can lead to a cascade of events, including a cytokine storm, intravascular thrombosis, and subsequent complications such as arterial and venous thromboses. COVID-19 can cause thrombocytopenia, lymphopenia, and neutrophilia, which are associated with worse outcomes. Prophylactic anticoagulation is essential to prevent complications and death rates associated with the virus’s effect on the coagulation system. It is crucial to recognize these complications early and promptly start therapeutic anticoagulation to improve patient outcomes. While rare, COVID-19-induced disseminated intravascular coagulation (DIC) exhibits some similarities to DIC induced by sepsis. Lactate dehydrogenase (LDH), D-dimer, ferritin, and C-reactive protein (CRP) biomarkers often increase in serious COVID-19 cases and poor prognosis. Understanding the pathophysiology of the disease and identifying risk factors for adverse outcomes is critical for effective management of COVID-19.
Funder
National Key Research and Development Programs of China Funding for Kunlun Talented People of Qinghai Province, High-end Innovation and Entrepreneurship Talents-Leading Talents
Subject
Microbiology (medical),Molecular Biology,General Medicine,Microbiology
Reference126 articles.
1. (2023, July 18). Coronavirus Disease (COVID-19) Pandemic. World Health Organization (WHO) (Cited 2023 June 12). Available online: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. 2. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The Species Severe Acute Respiratory Syndrome-Related Coronavirus: Classifying 2019-Ncov and Naming it SARS-CoV-2;Gorbalenya;Nat. Microbiol.,2020 3. Kim, K.S., Ejima, K., Iwanami, S., Fujita, Y., Ohashi, H., Koizumi, Y., Asai, Y., Nakaoka, S., Watashi, K., and Aihara, K. (2021). A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2. PLoS Biol., 19. 4. Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics;Standl;Lancet Infect. Dis.,2021 5. Cao, Z., Li, T., Liang, L., Wang, H., Wei, F., Meng, S., Cai, M., Zhang, Y., Xu, H., and Zhang, J. (2020). Clinical characteristics of coronavirus disease 2019 patients in Beijing, China. PLoS ONE, 15.
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