The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life

Author:

Sharma Anita1,Yu Yueyue2,Lu Jing2ORCID,Lu Lei2,Zhang Yong-Guo3,Xia Yinglin3ORCID,Sun Jun3ORCID,Claud Erika C.2

Affiliation:

1. Division of Pediatric Gastroenterology, C.S. Mott Children’s Hospital, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA

2. Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA

3. Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA

Abstract

Vitamin D signaling via the Vitamin D Receptor (VDR) has been shown to protect against intestinal inflammation. Previous studies have also reported the mutual interactions of intestinal VDR and the microbiome, indicating a potential role of probiotics in modulating VDR expression. In preterm infants, although probiotics have been shown to reduce the incidence of necrotizing enterocolitis (NEC), they are not currently recommended by the FDA due to potential risks in this population. No previous studies have delved into the effect of maternally administered probiotics on intestinal VDR expression in early life. Using an infancy mouse model, we found that young mice exposed to maternally administered probiotics (SPF/LB) maintained higher colonic VDR expression than our unexposed mice (SPF) in the face of a systemic inflammatory stimulus. These findings indicate a potential role for microbiome-modulating therapies in preventing diseases such as NEC through the enhancement of VDR signaling.

Funder

NIDDK/National Institutes of Health

DOD

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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