Affiliation:
1. Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
2. Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Luzhou 646000, China
Abstract
Cell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in the development of intestinal diseases. In recent years, the incidence of inflammatory bowel disease (IBD), colorectal cancer (CRC), and intestinal injury induced by intestinal ischemia–reperfusion (I/R), sepsis, and radiation have gradually increased, posing a significant threat to human health. The advancement in targeted therapies for intestinal diseases based on ferroptosis, necroptosis, and pyroptosis provides new strategies for treating intestinal diseases. Herein, we review ferroptosis, necroptosis, and pyroptosis with respect to intestinal disease regulation and highlight the underlying molecular mechanisms for potential therapeutic applications.
Funder
National Natural Science Foundation of China
Sichuan Science and Technology Program
Subject
Molecular Biology,Biochemistry
Cited by
4 articles.
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